Chemical chaperone therapy, a new strategy for genetic skin fragility disorders

Commentary: New advances in the development of therapies for treating inherited skin fragility disorders

Inherited skin fragility disorders comprise a group of disorders, mainly designated as epidermolysis bullosa (EB), that are characterised by mechanical induced blistering and erosions of the skin and mucous membranes caused by mutations of gene coding for protein components of the dermal–epidermal junction zone. Patients with EB experience various degrees of recurrent skin blistering, widesprea...

A Genetic-Fuzzy Control Strategy for Parallel Hybrid Electric Vehicle

Hybrid Electric Vehicles (HEVs) are driven by two energy convertors, i.e., an Internal Combustion (IC) engine and an electric machine. To make powertrain of HEV as efficient as possible, proper management of the energy elements is essential. This task is completed by HEV controller, which splits power between the IC engine and Electric Motor (EM). In this paper, a Genetic-Fuzzy control strategy...

a new approach to credibility premium for zero-inflated poisson models for panel data

هدف اصلی از این تحقیق به دست آوردن و مقایسه حق بیمه باورمندی در مدل های شمارشی گزارش نشده برای داده های طولی می باشد. در این تحقیق حق بیمه های پبش گویی بر اساس توابع ضرر مربع خطا و نمایی محاسبه شده و با هم مقایسه می شود. تمایل به گرفتن پاداش و جایزه یکی از دلایل مهم برای گزارش ندادن تصادفات می باشد و افراد برای استفاده از تخفیف اغلب از گزارش تصادفات با هزینه پائین خودداری می کنند، در این تحقیق ...

Is Medical Application Software a New Strategy for Oncologists?

A New Control Strategy for Controlling Isolated Microgrid

Microgrid control in isolated mode is a highly important subject area. In the present paper, a new method is used for controlling the isolated microgrids. This method was used based on the classification of the microgrids into two groups, namely fast-dynamic (battery and flywheel) and slow-dynamic (diesel generator, electrolyzer, fuel cell). For the microgrid components with fast dynamics, a se...